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Systemic Lupus Erythematosus (SLE) Could Affect Sperm Count and Fertility In Men

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Some of the recent studies have indicated that low sperm count in men may be directly linked to the lupus erythematosus. There are three main types of lupus namely - drug-induced lupus, discoid lupus erythematosus and lastly systemic lupus erythematosus (SLE), which is one of the most common diseases. Lupus or SLE is a chronic autoimmune disorder that causes painful joints, skin rash, swelling of joints, extreme fatigue and even kidney damage.

Usually your immune system produces special proteins named “antibodies” to protect your body from the invaders. When lupus hits, your immune system cannot differentiate between healthy tissues and foreign invaders. In this condition, your immune system automatically creates antibodies that destroy your healthy tissues. It ultimately results in chronic inflammation, joint pain and tends to damage every part of your body.

Now, you may wonder what lupus and its treatment has to do with your sperm count or fertility. In this article, we’ll be talking about the connection between lupus and fertility issues.

Lupus Linked to Infertility.

Though SLE autoimmune disease tends to affect females in their pregnancy period or reproductive years, it could also affect men. Researchers are concerned about future infertility issues in male SLE patients.

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Generally, the quality and quantity of sperm affects the fertility in men. In women, causes of infertility become more complex. The fertility rate in women with SLE is almost equal to that of normal women. However, over 50% pregnancies result in spontaneous abortion or premature birth.

Systemic lupus erythematosus, Graves' disease, multiple sclerosis and scleroderma share some of the clinical features. However, these diseases tend to affect women 4 to 5 times more than men. Researchers have confirmed that lupus can also lead to lower the production of specific testosterone and androgen in men. Still, men with lupus do not seem to be less masculine and sexually active than the ones without lupus.

What Study Says?

In the latest research, published in Arthritis & Rheumatism issues, scientists studied 25 male patients with SLE (systemic lupus erythematosus) and 25 healthy men.

Some extensive studies have shown that SLE is directly linked to lower motility, median testicular volume, and lower median sperm count. Individuals with SLE had lower sperm production rate and lower sperm volume. According to researchers, the sperm defects in the lupus patients are linked to the IV CYC treatment (intravenous treatment with the immunosuppressant cyclophosphamide).

Cytokines, Hormones, and other major immune factors, which are active in SLE, are directly affected by the sex hormones. Usually, estrogen increases the production of antibodies while testosterone decreases the antibody production. However, their role in the SLE still remains unclear to researchers. Some men affected by SLE are seen to have abnormal levels of androgen. In women, SLE causes lowered levels of thousands of active male hormones.

Lupus or SLE disease can be mild at first, but if left untreated, it could become life threatening. So, it’s recommended to treat lupus symptoms on time by consulting your doctor. With proper care, and proper medication, lupus can be treated without compromising with the quality of your life.

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